Dry Eye Problem   MOA   Efficacy   Experience

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SUBMIT
CLINICALLY PROVEN.
PRESERVATIVE-FREE
for all types of dry eye1,2

DRY EYE IS A DISEASE OF TEAR FILM DEFICIENCY


86% of dry eye sufferers have some form of evaporative dry eye,4 yet 80% of eye drops are not designed to address it5

SYSTANE® COMPLETE Preservative-Free
is a clinically proven solution for all types of dry eye1,2

NEXT GENERATION ARTIFICIAL TEAR TECHNOLOGY

An innovative formulation that features HP-guar and nano-lipid emulsion technology to provide
moisture retention and evaporation protection

HP-GUAR: THE KEY TO
HYDRATION RETENTION6

HP-guar is derived from guar gum and forms a viscous solution at low concentrations7

When exposed to the pH of the tear film and ocular surface, HP-guar forms a protective viscoelastic gel matrix that:6

  • Prolongs retention of the ingredients to protect the ocular surface
  • Mimics mucins in the tear film
  • Reduces friction between the eyelid and the ocular surface

HP-guar preferentially binds to dried-out or damaged hydrophobic regions of the cornea, helping to limit further damage6

Natural tears are viscous enough that they don’t evaporate too quickly, but fluid enough that they can spread to lubricate the ocular surface. HP-guar helps artificial tears mimic these properties.8

LIPID NANO-DROPLETS: ENHANCED SUPPORT FOR THE TEAR FILM9

SYSTANE® COMPLETE’S nano-sized droplets contain a complex of anionic phospholipid and mineral oil9

  • This technology allows for an optimal delivery system for lipids to the ocular surface and help protect the tear film from evaporation9,10
Lipid nano-droplets in SYSTANE® COMPLETE are formulated to provide better ocular surface coverage, promote tear film stabilization, and prolong retention of the demulcents.9
WATCH THE SYSTANE® COMPLETE FORMULATION IN ACTION

INSTANT AND ALL-DAY* SYMPTOM RELIEF WITH ONE DROP1

For patients with moderate-to-severe discomfort, dry eye symptom scores improved immediately,
and at 4 and 8 hours after administration of one drop of SYSTANE® COMPLETE1†‡

* 8 hours
Symptom improvements were consistent across all types of dry eye1

SYSTANE® COMPLETE DELIVERS LONG-TERM EFFICACY11*

SYSTANE® COMPLETE IMPROVES TEAR FILM
LIPID LAYER THICKNESS AND QUALITY11,12

SYSTANE® COMPLETE:

Significantly increased lipid layer thickness at 15 minutes post-instillation in patients with thin tear film lipid layer12*†
 

Significantly improved lipid layer grade vs. baseline over 90-180 days of use11§

Tear Film Lipid Layer Grade11

Ongoing daily lipid layer supplementation may impact the ocular surface and help restore tear film homeostasis, helping to break the vicious cycle of dry eye disease11

EYE CARE PROFESSIONALS (ECPs) AND PATIENTS
HAVE AN OVERWHELMINGLY POSITIVE EXPERIENCE
WITH SYSTANE® COMPLETE3*

ECPs’ Response

83% said they will definitely
recommend SYSTANE® COMPLETE to
their patients with dry eye to relieve
their symptoms (n=46)

Patients' Response

93% rated their experience with
SYSTANE® COMPLETE as
good/excellent (n=254)

References:
1. Silverstein S, et al. Symptom Relief Following a Single Dose of Propylene Glycol-Hydroxypropyl Guar Nanoemulsion in Patients with Dry Eye Disease: A Phase IV, Multicenter Trial. Clin Ophthalmol. 2020;14:3167-3177.
2. Yeu E, Silverstein S, Guillon M, et al. Efficacy and safety of phospholipid nanoemulsion-based ocular lubricant for the management of various subtypes of dry eye disease: A Phase IV, Multicenter Trial. Clin Ophthalmol. 2020; 14:2561-2570.
3. Alcon Data on File, 2019.
4. Lemp MA, Crews LA, Bron AJ, Foulks GN, Sullivan BD. Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea. 2012;31:472–478.
5. Alcon data on file, 2021B.
6. Srinivasan S, Manoj V. A Decade of Effective Dry Eye Disease Management with Systane Ultra (Polyethylene Glycol/Propylene Glycol with Hydroxypropyl Guar) Lubricant Eye Drops. Clin Ophthalmol. 2021;15:2421-2435.
7. Petricek I, et al. Hydroxypropyl-guar gellable lubricant eye drops for dry eye treatment. Expert Opin Pharmacother. 2008. 9(8): 1431-6.
8. Rangarajan R, Kraybill B, Ogundele A, Ketelson H. Effects of a hyaluronic acid/hydroxypropyl guar artificial tear solution on protection, recovery, and lubricity in models of corneal epithelium. J Ocul Pharmacol Ther. 2015;31(8):491-497.
9. Rangarajan R, Ketelson H. Pre-clinical evaluation of a novel phospholipid nanoemulsion based lubricant eye drops. Poster presented at: The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO); May 7–11, 2017. Baltimore, Maryland, USA
10. Lallemand F, et al. Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb. J Drug Delivery. 2012;2012:604204.
11. Craig JP, et al. Developing evidence-based guidance for the treatment of dry eye disease with artificial tear supplements: A six-month multicentre, double-masked randomised controlled trial. Ocul Surf. 2021;20:62-69.
12. Weisenberger K, Fogt N, Swingle Fogt J. Comparison of nanoemulsion and non-emollient artificial tears on tear lipid layer thickness and symptoms. J Optom. 2021;14(1):20-7.
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